Abstract
A series of new water soluble Ru(III) pyrazole complexes mer-[RuCl3(DMSO-S)(pyz)2] 1, mer-[RuCl3(DMSO-S)(DMSO-O)(pyz)] 2, mer-[RuCl3(bpy)(dmpyz)] 3, and mer-[RuCl3(DMSO-S)(dmpyz)2] 4 (pyz=pyrazole; dmpyz=3,5-dimethylpyrazole, bpy=2,2’-bipyridine) have been synthesized and characterized by use of a combination of spectroscopy (IR and UV-visible), X-ray diffraction, and cyclic voltammetry. The molecular X-ray structure of all reported compounds (1–4) revealed distorted octahedral coordination around ruthenium. The cytotoxicity assay on human breast cancer cells (MCF7) demonstrated that compounds 1 and 4 affect cell viability, whereas compounds 2 and 3 do not show appreciable activity. The IC50 values for 1 and 4 lie within the range of 71–32μM in MCF7 cells.
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