Abstract
A set of new diastereopure unsymmetrical α-diimine ligands 2a– d derived from methylglyoxal and optically pure primary amines 1a– d afforded the new chiral Pd(II)-complexes ( S, S)- 3a, ( S, S)- 3b, ( S, S)- 3c, and (1 S, 2 S, 3 S, 5 R)- 3d. All compounds have been characterized by IR, 1H, and 13C NMR spectroscopies along with MS-FAB + spectrometry. The crystal and molecular structure for the complexes 3a, 3b and 3d have been fully confirmed by single-crystal X-ray studies. Likewise, complexes 3a– d have also been screened for their in vitro cytotoxicity against different classes of cancer: leukemia (K-562 CML), colon cancer (HCT-15), human breast adenocarcinoma (MCF-7), central nervous system (U-251 Glio) and prostate cancer (PC-3) cell lines.
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