Abstract
BackgroundPipemidic acid, like other quinolones, is susceptible against different organisms in vitro, and it was proved to be a preferred choice for certain indications. Previous studies reveal that concurrent administration of essential and trace elements with quinolones decreases gastrointestinal absorption, causing therapeutic failure. To study the probable interaction of pipemidic acid with essential and trace elements present in the human body, pipemidic acid has been reacted with magnesium, calcium, chromium, manganese, iron, cobalt, nickel, copper, zinc, and cadmium, the complexes formed.ResultsThe compounds were characterized by the melting point, conductance studies, IR, UV, 1H-NMR, CHN, and atomic absorption analysis.ConclusionThe results suggested oxygen atoms present at carbonyl and carboxylic group render the bidentate6 property to the pipemidic acid. The antimicrobial activity of the compounds was determined by the disk diffusion method, and both standard and complexes show no antibacterial activity against the clinical isolates.
Highlights
Pipemidic acid, like other quinolones, is susceptible against different organisms in vitro, and it was proved to be a preferred choice for certain indications
Metals were estimated on a Pye-Unicam atomic absorption spectrophotometer to determine the ratio of drug metal complexation
The essential and trace elements were used in the form of the following hydrated salts: magnesium chloride hexahydrate (MgCl2.6H2O), calcium chloride dihydrate (CaCl2.2H2O), chromium chloride hexahydrate (CrCl3.6H2O), manganese chloride monohydrate
Summary
Like other quinolones, is susceptible against different organisms in vitro, and it was proved to be a preferred choice for certain indications. Previous studies reveal that concurrent administration of essential and trace elements with quinolones decreases gastrointestinal absorption, causing therapeutic failure. To study the probable interaction of pipemidic acid with essential and trace elements present in the human body, pipemidic acid has been reacted with magnesium, calcium, chromium, manganese, iron, cobalt, nickel, copper, zinc, and cadmium, the complexes formed. Results: The compounds were characterized by the melting point, conductance studies, IR, UV, 1H-NMR, CHN, and atomic absorption analysis. Pipemidic acid and its complexes have inhibitory action against Escherichia. Metals were estimated on a Pye-Unicam atomic absorption spectrophotometer to determine the ratio of drug metal complexation
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