Abstract
We synthesized a new Schiff base ligand by condensation reaction of 4-dimethylaminobenzaldehyde and 1,3-phenylenediamine. Treatment of this Schiff base ligand with Zinc(II) nitrate and Cadmium(II) nitrate in ethanol medium afforded the corresponding metal complexes. The synthesized ligand and complexes were characterized by their UV-Vis, FT-IR and 1 H-NMR, 13 C-NMR spectral data and elemental analysis. The spectral data suggest an octahedral geometry for these complexes. Antibacterial activities of both synthesized free ligand and complexes were investigated against Escherichia coli , Staphylococcus aureus , and Bacillus subtilis bacteria. The complexes showed better antibacterial activity in comparison with that of the free ligand against selective bacteria. Keywords: New Schiff base ligand, 4-dimethylaminobenzaldehyde, Zn(II), Cd(II) complexes, antibacterial activity
Highlights
A significant increase in the rate of mortality of people exposed to infectious diseases is very important and a concerning issue
The effect mechanism of antimicrobial agents is dependent on two factors: a) the bacteria’s structure; b) the function affected by the agent which these two factors are as follow: 1) Obstruction of ribosome function folate metabolism and nucleic acid synthesis
In this paper, new Schiff base ligand obtained by condensation reaction of 4-dimethylaminobenzaldehyde and 1,3-phenylenediamine give new N,N’-bis(4-dimethylamino benzylidene)benzene-1,3-diamine which is characterized by the spectral analysis
Summary
A significant increase in the rate of mortality of people exposed to infectious diseases is very important and a concerning issue. Chelation reduces the polarity of the metal ion because of overlapping of the ligand orbital and partial sharing of the positive charge of the metal ion.[4,5] the complex may penetrate into the lipid membranes which may disable the enzymes of microorganisms by blocking their metal binding sites Such complexes frustrate the respiration of the cell and as a result the growth of the organism is restricted by disturbing the protein synthesis.[6] The effect mechanism of antimicrobial agents is dependent on two factors: a) the bacteria’s structure; b) the function affected by the agent which these two factors are as follow: 1) Obstruction of ribosome function folate metabolism and nucleic acid synthesis. The effect mechanism of antimicrobial agents is dependent on two factors: a) the bacteria’s structure; b) the function affected by the agent which these two factors are as follow: 1) Obstruction of ribosome function folate metabolism and nucleic acid synthesis. 2) Blockage of cell membrane function, and cell wall synthesis
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