Abstract
A new ligand 2,3-dihydrobenzo [d] thiazole-2-carboxylic acid (L) has been prepared from the reaction of ortho amino phenyl thiol with dichloroacetic acid in mole ratio (1:1). It has been characterized by elemental analysis (C.H.N.), IR, UV- Vis.spectraand 1H, 13C-NMR. A new series complexes of the bivalent ions (Co, Ni, Cu, Pd, Cd, Hg and Pb) and the trivalent (Cr) have been prepared and characterized too. The structural has been established by elemental analysis (C.H.N.), IR, UV-Vis. spectra, molar conductivity, atomic absorption and magnetic susceptibility measurements. The synthesized complexes were prepared in (1:2) ratio correspond to (Co(II), Ni(II), Cu(II), Pd(II), Cd(II), Hg(II) and Pb(II) complexes while in case Cr(III) complex is (1:1) ratio (M:L). ?, Kf for (Cr(III), Co(II), Ni(II) and Cu(II)) were estimated too. The complexes showed characteristics octahedral geometry with the (O,N) ligand coordinated in bidentate mode except with Pd showed square planer. The study of biological activity of ligand (L) and its complexes showed various activities toward Staphylococcus aureusand E. coli.
Highlights
The interaction of metal complexes with biological system, which is the field of bio-coordination chemistry draws increasing interest[1,2]
Attentions have been paid during the last decade for the chemistry of the metal complexes of ligands containing nitrogen and oxygen
This could be due to the stability of such ligands complexes and its biological activity in oxidation catalysis and electro chemical analysis[8]
Summary
The interaction of metal complexes with biological system, which is the field of bio-coordination chemistry draws increasing interest[1,2]. It plays many important roles in electron transfer agents, as catalysts, and in photosynthesis[3]. Inorganic elements play crucial roles in biological and biomedical processes and, it is evident that many organic compounds used in medicine do not have a purely organic mode of action[4], some are activated or biotransformed by metal ions including metallozymes, other have directed indirect effect on metal ion metabolism[5]. This could be due to the stability of such ligands complexes and its biological activity in oxidation catalysis and electro chemical analysis[8]. In present work 2,3-dihydrobenzo [d] thiazole-2carboxylic acid with (Cr(III), Co(II), Ni(II), Cu(II), Pd(II), Cd(II), Hg(II) and Pb(II)) are synthesized and their physical properties, biological activity were investigated
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