Abstract
Coumarin derivatives have shown different biological activities, such as antifungal, antibacterial antiinflammatory, and antioxidant activities, besides antibiotic resistance modulating effects, and anti-HIV, hepatoprotective, and antitumor effect. So, new coumarin derivatives (hydrazones and an amide) were synthesized through multisteps reactions. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis. The compounds then evaluated for their anti-bacterial activity by means of well-diffusion method against two gram-positive bacteria (Staphylococcus aureus, Streptococcus pneumoniae) and two gram-negative bacteria (E.coli and Pseudomonas aeruginosa). The highest activity was demonstrate by compound k2 which found to be highly active against pseudomonas aeruginosa.
Highlights
Heterocyclic chemistry is one of the main parts in organic chemistry and it is growing quickly
The synthesis of A and B was done by reaction of coumarin-3-carboxylic acid with hydrazine hydrate and diethyl amine, respectively, in the presence of coupling agent (EDCI) and catalyst (HOBT)
Compounds A, B were synthesized by the reaction of coumarin 3 carboxylic acid with hydrazine hydrate (NH2NH2.H2O) or amines
Summary
Heterocyclic chemistry is one of the main parts in organic chemistry and it is growing quickly. Coumarin (which is referred 1,2-benzopyrone or less commonly, as o-hydroxycinnamic acid-8lactone) a natural heterocyclic organic aromatic compound, present in a widespread variability of microorganisms and higher plants [3,4], vogel was first one who insulate coumarin in 1820 by extracting from the tonka beans (Dipteryx odorata) specie previously known as Coumarona odorata, later the term coumarin. It has been identified in a huge number of the plants which belong to numerous diverse families[5]
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