Abstract
Carboxamide complexes having general formula as [ML]Cl2·nH2O (where M = Cu(II), Zn(II); n = 0, 1/2) were synthesized using heterocyclic carboxamide ligands: 1,4-bis[3-(2-thiophenecarboxamido)propyl]piperazine (L1) and 1,4-bis[3-(2-furancarboxamido) propyl]piperazine (L2). Their structures were characterized with elemental analysis, molar conductivity, magnetic susceptibility, and spectral methods (1H-NMR, 13C-NMR, FT-IR, LC-MS). TGA and DTA curves were also performed. The structure–activity relationship for the ligands was investigated using PM3 semi-empirical method. The antibacterial activities of the carboxamides and their complexes were investigated against bacteria; Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 11230, Bacillus magaterium RSKK 5117, B. cereus RSKK 863, Salmonella enteritidis ATCC 13076, B. subtilis RSKK 244 using microdilution method.
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