Abstract
Six new complexes of Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) with substituted benzofuran derivatives have been synthesized and characterized by elemental analysis, magnetic moments, conductance measurements, spectral characterization, and so forth. Elemental data coincide with the general formula MLC1n, where L = (E)-7-Methoxy-N1-(2,4,5-trimethoxy benzylidene) benzofuran-2-carbohydrazide (L1) or (E)-N1-(2,6-dichloro benzylidene)-7-methoxy benzofuran-2-carbohydrazide (L2), of the complexes. The ligands coordinate to the metal ions through the oxygen of the carbonyl group and the nitrogen of the hydrazine group. Electronic spectral data of the complexes suggests the probable geometry is octahedral in nature. All the complexes and ligands were screened for their antibacterial activity. Among them, Co, Ni, and Cu complexes of L2 showed good activity against all microbes.
Highlights
Schiff ’s bases are the most widely studied chelating ligands in coordination chemistry [1]
We thought it is worthwhile to synthesis and characterize the benzofuran based ligands and their transition metal complexes and investigate their antimicrobial properties
As a part of our ongoing study on benzofuran derivatives [6, 7, 22,23,24], we report the synthesis, characterization, and antibacterial activity of (E)-7-Methoxy-N1-(2,4,5-trimethoxy benzylidene) benzofuran-2-carbohydrazide (L1) and (E)-N1-(2,6-dichloro benzylidene)-7-methoxy benzofuran2-carbohydrazide (L2) and their metal complexes such as Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) as shown in Scheme 1
Summary
Schiff ’s bases are the most widely studied chelating ligands in coordination chemistry [1]. They are useful in catalysis in organic synthesis and in medicine as antibiotics, antiallergic, and antitumor agents [2]. Metal complexes of Schiff ’s bases derived from carbonyl compounds based on heterocyclic rings have been the centre of attraction in many areas [3,4,5,6,7]. Benzofuran based fused heterocycles have been of great interest as they are abundant in nature and have wide pharmacological activities [8]. We thought it is worthwhile to synthesis and characterize the benzofuran based ligands and their transition metal complexes and investigate their antimicrobial properties
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