Abstract
New complexes of the some trivalent transition metal ions of the uracil such as [M(Ura)3Cl3] and mixed ligand metal complexes with uracil and oxalic acid [M(Ura)2(OA)(OH2)Cl].H2O type, where (Ura)=Uracil, (OA= Oxalic acid dihydrate, (M= Cr+3 and Fe+3) were synthesized and characterized by the elemental analysis, FT.IR, electronic spectra, mass spectra and magnetic susceptibility as well as the conductivity measurements. Six–coordinated metal complexes were suggested for the isolated complexes of Cr+3 and Fe+3 with molecular formulas dependent on the nature of uracil and oxalic acid present. The proposed molecular structure for all complexes with their ions is octahedral geometries. The antibacterial efficiency was tested of metal salts, ligands and metal complexes to the pathogenic bacteria activity have been studied.
Highlights
Coordination complexes are recognized by mixed ligands to play a significant role in biological systems [1,2]. 2,4(1H, 3H)- Pyrimidinedione commonly called through the trivial name Uracil (Ura) was known since 1900 while it was first secluded through hydrolysis of materials including RNA [3,4].Other names of (Ura) is 2Oxy - 4-Oxy pyrimidine or 2, 4 - dihydroxy pyrimidine or 2,4 pyrimidine diol,(Ura) structure is shown at Figure1. (Ura) can as well link for a ribose sugar into composing the ribonucleoside uridine
Uracils have represented a category of compounds that consistently engage organic chemist, biochemists, medicinal chemists and photo biologists [7,8,9,10]. (Ura) was detected as RNA components, of which prepared through hydrolysis
On (OA) spectrum, it was shifted into lower wave number on spectra for mixed ligand compounds with Cr+3 and Fe+3(Ura) (OA) complexes, representing coordination for a carboxylic group with metal ions through the oxygen atom, that provides the monotonicity of carboxylate group [36]
Summary
Coordination complexes are recognized by mixed ligands to play a significant role in biological systems [1,2]. 2,4(1H, 3H)- Pyrimidinedione commonly called through the trivial name Uracil (Ura) was known since 1900 while it was first secluded through hydrolysis of materials including RNA [3,4].Other names of (Ura) is 2Oxy - 4-Oxy pyrimidine or 2, 4 - dihydroxy pyrimidine or 2,4 pyrimidine diol,(Ura) structure is shown at Figure1. (Ura) can as well link for a ribose sugar into composing the ribonucleoside uridine. Various (Ura) derivatives have been preceded like drugs, so, methylthiouracil [11], propylthiouracil are thyroid inhibitors [12], Uramustine (Uracil mustard) [13,14], Fluorouracil [15,16], and its masked compounds are anticancer agents. The latter interest at the preparation and structural realization from palladium(II) and platinum(II) compound for (Ura) can be referred into a part on the significance from these compoundslike catalyst,anti-cancerous drugs, and biology effective compounds. It was found that antimicrobial efficiency from several aliphatic carboxylic complexes is higher that the activity from the associated carboxylic acid for zinc (II) compounds [28]
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