SYNTHESIS, CHARACTERIZATION AND ANTI-INFLAMMATORY ACTIVITY OF SOME HYDRAZONE DERIVATIVES

Abstract

A mixture of phenyl acetic acid (10gm, 0.003mole) in acetone, dimethyl Sulphate (10.45ml, 0.007mole), anhydrous potassium carbonate (2.8gm, 0.02mol) was refluxed on a water bath for 2 hr with occasional stirring give methyl 2-phenylacetate(1), Methyl 2-phenylacetate (1.78gm, 0.01mole) in alcohol was refluxed with hydrazine hydrate (0.38gm, 0.01mole) for 8hrs formed 2-phenylacetohydrazide, A mixture of substituted benzaldehyde (1.22gm, 0.01mole) and 2-phenyl acetohydrazide (1.5gm, 0.01mole) were dissolved in methanol then two drops of conc. HCl were added as catalyst and stirred at room temperature for 2hr formed N'-(2-chlorobenzylidene)-2-phenylacetohydrazide,N'-(3,4,5-trimethoxybenzylidene)-2-phenylacetohydrazide, N'-(furan-2-ylmethylene) -2-phenylacetohydrazide, and N'-(3,4,5-trimethoxybenzylidene) -2-phenylacetohydrazide Key-Words: Phenyl acetic acid, Hydrazine-hydrate, NSAID’S, Anti-inflammatory.