Abstract
Objective: The objective of this study was to synthesize and evaluate the anthelmintic activity (AA) of novel benzothiazole derivatives containing indole moieties (BDIM).
 Methods: The present works which involve the substituted isatin Schiff bases undergo acetylating and reacting with 2-aminobenzothiazole to give novel BDIM.
 Results: All the newly synthesized molecules (5a-5o) were characterized by Fourier-transform infrared spectroscopy, H_nuclear magnetic resonance, and mass spectral analysis along with physical data. The biological potentials of the newly synthesized compounds are evaluated for their AA using an Indian earthworm (Pheretima posthuma), and albendazole was used as standard drug.
 Conclusion: The synthesized compound 5f, 5n, and 5o showed good AA, whereas others exhibited significant activities.
Highlights
Heterocyclic compounds are those which have a cyclic structure with two, or more, different kinds of atom in the ring
The synthesized compounds were screened for anthelmintic activities [4,5,6,7]
The IR spectra were recorded on a Shimadzu 8700 spectrometer using the ATR technique (Attenuated Total Reflectance) in the range of 400–4000 cm-1. and values are reported in cm-1 and the spectra were interpreted.1H-nuclear magnetic resonance (NMR) spectra were recorded on DPX-200 MHz NMR spectrometer using dimethyl sulfoxide (DMSO)-d6 and chemical shifts (δ) are reported in parts per million downfield from internal reference tetramethylsilane,and the spectra were interpreted
Summary
Heterocyclic compounds are those which have a cyclic structure with two, or more, different kinds of atom in the ring. This two kinds of atoms are like carbon and the other elements (heteroatoms), most often N, O and S. Benzothiazole is not widely used, many of its derivatives are found in commercial products or in nature[1-3 ]. Benzothiazole ring found to be possessing pharmacological activities such as antitumor, antitubercular, antimalarial, anticonvulsant, anthelmintic, analgesic, anti inflammatory and antifungal. Isatin or 1H-indole-2, 3-dione is an indole derivative. Indole derivatives have acquired conspicuous significance due to their wide spectrum of biological activities
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