Synthesis, characterization, and α‐glucosidase, cholinesterases, and tyrosinase inhibitory effects of axial substituted silicon and peripheral tetra‐substituted copper (II), manganese (III) phthalocyanines

Abstract

In this paper, we have synthesized axially di‐(3,3‐diphenylpropoxy) substituted silicon (DFP‐Si) and peripherally tetra‐(3,3‐diphenylpropoxy) substituted copper (II), manganese (III) phthalocyanines (DFP‐Cu, DFP‐Mn). Then, the α‐glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase inhibitory effects of DFP‐Si, DFP‐Cu, and DFP‐Mn were examined using spectrophotometric methods. DFP‐Mn had the highest inhibitor effect on cholinesterases, tyrosinase, and α‐glucosidase in a concentration‐dependent manner. DFP‐Mn inhibited α‐glucosidase with IC50 value of 17.80 μM. Also, DFP‐Mn also showed higher α‐glucosidase inhibitory actions that acarbose used as a positive control. The inhibition percentages in the presence of DFP‐Mn were 30.64 ± 2.24%, 51.96 ± 1.56%, and 72.96 ± 4.95%, respectively at 20, 40, and 100 μM on AChE. In the presence of DFP‐Mn at 100 μM, the inhibition percentages were calculated as 52.18 ± 2.22% against tyrosinase. These results showed that the compound has potential to treat Diabetes mellitus but further studies are needed to confirm the antidiabetic effect of the compound.