Abstract
Ni (II) and Cd (II) complexes containing hydrazine as ligand and cinnamic acid as co-ligand were synthesized and characterized by hydrazine and metal analyses, thermal analysis and FT-IR spectral studies. It has been found that hydrazine behaves as bidentate ligand and cinnamate as monodentate ligand in the complexes. The biological activities of complexes have been evaluated against two gram negative (Escherichia coli and Pseudomonas aeruginosa) and two gram positive (Bacillus subtilis and Staphylococcus aureus) bacteria by Agar diffusion disc method. It has been found that the complexes have potent activity against the bacteria.
Highlights
The field of bioinorganic chemistry, which deals with the study of role of metal complexes in biological systems, has opened a new horizon for scientific research in coordination compounds
Hydrazine carboxylates of the transition metal ions with variety of acids have been reported. These include simple aliphatic mono carboxylic acid, (Sivasankar and Govindarajan, 1995; Sivasankar and Govindarajan, 1997; Sivasankar and Govindarajan, 1994) aliphatic dicarboxylic acids, (Gold, 1987; Govindarajan et al, 1995; Sivasankar, and Govindarajan, 1994; Vikram and Sivasankar, 2007; Vogel, 1985) aromatic mono and dicarboxylic acids (Kuppusamy, and Govindarajan, 1995; Kuppusamy and Govindarajan, 1996) and heterocyclic acids. (Premkumar and Govindarajan, 2006; Von Burg and Stout, 1991) The present paper describes the synthesis, analytical, spectral, thermal studies of Ni (II) and Cd (II) metal complexes containing hydrazine and cinnamic acid
Antibacterial analysis of the complexes was evaluated among the different bacterial strains such as Escherichia coli, Pseudomonas aeruginosa, Bacillus subtilis and Staphylococcus aureus
Summary
The field of bioinorganic chemistry, which deals with the study of role of metal complexes in biological systems, has opened a new horizon for scientific research in coordination compounds. (Premkumar and Govindarajan, 2005; Yasodhai and Govindarajan, 2000) Hydrazine and their metal complexes have played an important role in the development of coordination chemistry. Hydrazine carboxylates of the transition metal ions with variety of acids have been reported. These include simple aliphatic mono carboxylic acid, (Sivasankar and Govindarajan, 1995; Sivasankar and Govindarajan, 1997; Sivasankar and Govindarajan, 1994) aliphatic dicarboxylic acids, (Gold, 1987; Govindarajan et al, 1995; Sivasankar, and Govindarajan, 1994; Vikram and Sivasankar, 2007; Vogel, 1985) aromatic mono and dicarboxylic acids (Kuppusamy, and Govindarajan, 1995; Kuppusamy and Govindarajan, 1996) and heterocyclic acids. These include simple aliphatic mono carboxylic acid, (Sivasankar and Govindarajan, 1995; Sivasankar and Govindarajan, 1997; Sivasankar and Govindarajan, 1994) aliphatic dicarboxylic acids, (Gold, 1987; Govindarajan et al, 1995; Sivasankar, and Govindarajan, 1994; Vikram and Sivasankar, 2007; Vogel, 1985) aromatic mono and dicarboxylic acids (Kuppusamy, and Govindarajan, 1995; Kuppusamy and Govindarajan, 1996) and heterocyclic acids. (Premkumar and Govindarajan, 2006; Von Burg and Stout, 1991) The present paper describes the synthesis, analytical, spectral, thermal studies of Ni (II) and Cd (II) metal complexes containing hydrazine and cinnamic acid
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