Abstract
N-[5-(3-Aminopropylamino)-10-methyl-9 H-benzo[ a]phenoxazin-9-ylidene]ethanaminium chloride (Bze-NH 2) was prepared and used as a precursor in the synthesis of new polycyclic cationic dyes. In addition to the potentiality of Bze-NH 2 as a non-covalent fluorescent probe, the presence of a free amino group in its structure prompted us to study the application of this functionalised heterocycle in the covalent labelling of glycine and valine amino acids, as models of biomolecules. All compounds obtained showed strong absorbance and high emission at long-wavelengths ( λ em >640 nm). Furthermore, all benzo[ a]phenoxazine derivatives synthesised were evaluated as antifungal agents against Saccharomyces cerevisiae, considering the commercial Nile Blue A (NB) as a lead compound. The results revealed that they exhibited good activity, which was usually superior to NB, the most effective compound displaying a minimum inhibitory concentration (MIC) value of 15 μM.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
