Abstract
A new ligand namely 3-hydroxybenzaldehyde-4-nitrobenzoic acid hydrazone, its Nickel(II) and Copper(II) complexes were synthesised and characterised by spectroscopic methods: <sup>1</sup>H NMR, Infrared (IR), UV-Vis, magnetic susceptibility measurement and % metal analysis. <sup>1</sup>H NMR spectroscopy showed the diagnostic N-H signal at 12.10 ppm indicating the formation of the ligand. Infrared spectra showed that the ligand coordinated to the metal ion in keto form through the carbonyl oxygen (C=O) and the azomethine nitrogen (C=N). The UV-Vis spectrum of the ligand displayed two prominent bands at 47169 cm<sup>-1</sup> and 30303 cm<sup>-1</sup> which were ascribed to the intraligand transitions of π-π*, and n-π* respectively. These bands had hypsochromic shifts in the metal complexes indicating coordination with the metal ion. The nickel complex had a magnetic moment of 2.92 B.M, suggesting an octahedral geometry, while the copper complex had a value of 1.65 B.M. which is close to the expected value for a d<sup>9</sup> copper(II) complex with possibility antiferromagnetic interactions. The % metal calculated had a good agreement with the observed values. The acetylcholinesterase inhibition activity of the ligand measured was 190 ± 20 μg/mL compared to the standard Eserin that had 68 ± 1.13 μg/mL. The copper(II) complex had a value of 220 ± 20 μg/mL, while the Nickel(II) complex had the least inhibitory value at 390 ± 80 μg/mL. The compounds could serve as primary target in the study of acetylcholinesterase inhibitors
Highlights
Alzheimer’s disease (AD) is the most common form of dementia among older people and the pathogenesis of this disease is associated with oxidative stress
Acetylcholinesterase inhibition activity of hydrazones derived from condensation of Gallic hydrazide with some ketones were studied and it was found
The synthesised compounds were characterised by various physicochemical methods such as 1H NMR, IR, UVVis and magnetic measurement
Summary
Alzheimer’s disease (AD) is the most common form of dementia among older people and the pathogenesis of this disease is associated with oxidative stress. It is a chronic neurodegenerative and progressive disease, and is characterised by progressive impairment of memory and cognition, mood changes, and problems with communication and reasoning [1, 3]. Hydrazones have interesting biological activities and have attracted great attention in the last decades [25, 26)]. There are reports that hydrazone compounds show profound acetylcholinesterase inhibition activities [10,11,12]. Acetylcholinesterase inhibition activity of hydrazones derived from condensation of Gallic hydrazide with some ketones were studied and it was found
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