Abstract
A series of biologically active some novel (E)-(4-(2-(benzo [d] thiazol-2-yl) hydrazono)-3-methyl-2,6-diphenylpiperidin-1-yl)(phenyl) methanone derivatives (14-19) were synthesized and characterized by IR, 1H NMR, 13C NMR and HSQC spectral analysis. Molecular docking studies were also carried out for compounds 14-19 using the crystal structure of Ribonucleotide Reductase to disclose the binding mode and orientation of target molecule into the active site of respective receptors. The synthesized compounds were also screened for their antimicrobial activity against selected panel strains Antimicrobial studies revealed that the synthesized compound 14 exhibited noticeable activity against B.cerus whereas compounds17 and 18 displayed appreciable activity against K.pneumoniae. Bromo substituted phenyl group at C-2 and C-6 of piperidine ring showed excellent antibacterial activity against K.pneumoniae and B.cerus at MIC of 25μg/ml. The antifungal studies revealed that compounds 17, 18 and 19 exposed significant antifungal activity against the pathogenic strains used in this study. In particular compound 19 are showed excellent antifungal activity against C.albicans and A.niger.
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