Synthesis, Biochemical Evaluation and Rationalisation of the Inhibitory Activity of a Series of 4-Substituted Phenyl Alkyl Triazole-Based Compounds as Potential Inhibitors of 17α-Hydroxylase/17,20-Lyase (P45017α)

Abstract

We report the preliminary results into the synthesis and evaluation of triazole-based compounds against the components of 17α-hydroxylase/17,20-lyase (P45017α), namely 17α-hydroxylase (17α-OHase) and 17,20-lyase (lyase). The results show that the compounds are weaker than ketoconazole but are good lead compounds in the search for inhibitors of P45017α, in particular, lyase. Keywords: 17α-hydroxylase, 17,20-lyase, P45017α, Synthesis, Evaluation, Triazole