Synthesis, biochemical and histological study of captopril derivatives as a possible drug for diabetes

Abstract

The aim of the research is to synthesis one of the captopril derivatives by converting the carboxyl group to the nitrile group, and characterized by (FTIR, 1H-NMR, 13CNMR, Mass spectroscopy and CHNS). This process converts captopril structure design to a compound similar to the modern diabetes drugs(vildagliptin), with continuation of its effectiveness as an antihypertensive drug.After preparation of the modified drug, the effectiveness confirmed by some related enzymes, hormones, and some histological pictures of experiment animals(rabbits). The effects of the derivative on rabbits were studied. sixty rabbits with weights (1500- 1800)g, were divided into six groups (10 rabbits for each group) -The first group, G1 consisting of 10 rabbits, is a healthy control group that has not been given any substance.-The second group, G2 alloxan group (infected group) -The third group get the alloxan and vildagliptin -The fourth group get the alloxan and the modified drug compared to vildagliptin dose.-The fifth group get the alloxan and the modified drug compared to captopril dose. The sixth group get the alloxan and the captopril. After two weeks, the samples were withdrawn after 2 hours from the last dose, the serum was separated and the biochemical and enzymatic variables were studied including (glucose, insulin hormone, glucagon hormone, dipeptidyl peptidase-4, angiotensin converting enzyme , Endothelium-derived hyperpolarizing factors, prostaglandin I2, bradykinin, nitric oxide, alkaline phosphatase, aspartate amino transferase, alanine amino transferase, Urea, Creatinie)