Abstract
A novel triprotected hydrazine reagent, 1,2-Boc 2-2-Z-hydrazine ( 3),-has been made and investigated with respect to stepwise alkylation/acylation and intermediary deprotection in order to prepare multisubstituted hydrazine derivatives. Alkylation of 3 requires particularly mild basic conditions. Regiospecific cleavage of one Boc-group with acid in monoalkylated product 4 is difficult but can be accomplished with catalytic amounts of Mg(ClO 4) 2 in MeCN at 50 °C in 15 min, furnishing 5 which can easily be alkylated to 6. This product has recently been converted to fully substituted derivatives 7.
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