Abstract
The 2-phenyl-benzoxazin-4-ones were condensed with primary amine to form the 2,3-disubstituted quinazolin-4(3H)-ones. Their chemical structure was elucidated by means of spectral (FT-IR, 1H-NMR, MS) and elemental analysis. The antiviral activity and cytotoxicity of the compounds were tested in HeLa cells (vesicular stomatitis virus, Coxsackie virus B4 and respiratory syncytial virus), HEL cells [herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), vaccinia virus], Vero cells (parainfluenza-3, reovirus-1, Sindbis virus, Coxsackie virus B4 and Punta Toro virus). Among the new derivatives evaluated, specific antiviral activity was noted with compound QAA against vaccinia virus, parainfluenza-3 virus and Punta Toro virus, compound QOPD against HSV-1, HSV-2 and vaccinia virus, and compounds QONA and PD-NFIN against Coxsackie virus B4. Key words: Quinazoline, antiviral, HSV, vaccinia, sulphanamides.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.