Synthesis, antitumor and antiviral properties of some 1,2,4-triazole derivatives

Abstract

A series of 1,5-dialkyl-1,2,4-triazole derivatives of acetic acid alkylidene hydrazides 8–12, the acid 13, 1,5-dialkyl-3-(5-mercapto-4- N-aryl-1 H-[1,2,4]-triazol-3-ylmethylene)-1 H-[1,2,4] triazoles 14–16, their 1,3,4-oxadiazole analogues 17–21, as well as the 1,2,4-triazolo-indoles 25 and 27 were prepared. The Z/E conformations of some acetic acid alkylidene derivatives were studied by NMR spectroscopy. Most of the target compounds were evaluated in a series of human cancer cell in cultures and none have shown activity except 25 which exhibited remarkable activity against nine cancer types. No in vitro antiviral activity against HIV-1, HIV-2, HSV-1, HSV-2, SV, CV-B4, RSV, P3V, RV, SinV, PTV has been found for all the synthesized compounds.