Abstract
Thiosemicarbazones are a class of compounds of interest for Medicinal Chemistry, as they are structurally diverse and have numerous biological activities reported in the literature. This study describes the synthesis of seventeen thiosemicarbazones, which were investigated as potential therapeutic agents for the treatment of Alzheimer's disease through antioxidant tests and an inhibitory assay of the acetylcholinesterase enzyme. All compounds showed excellent inhibition of acetylcholinesterase and exhibited excellent antioxidant action when compared to the standards. In addition, a quantum study was carried out, in which the HOMO (highest occupied molecular orbital) and LUMO (lowest unoccupied molecular orbital) energy values of each compound were obtained. From these theoretical data, chemical properties were calculated and correlated with the experimental data.
Highlights
Free radicals are reactive molecules containing an unpaired electron or an odd number of electrons.[1]
All synthesized compounds were unequivocally characterized by their melting points, IR, 1H nuclear magnetic resonance spectroscopy (NMR), and 13C NMR, and the structures were confirmed by High-resolution mass spectra (HRMS)
In the compound’s 1H NMR spectra, a singlet signal at the 2.30-2.39 region is attributed to a CH3 moiety, and aromatic hydrogens appear at 6.5-8.5 ppm, depending on the substituent in the aromatic (Ar) group
Summary
Free radicals are reactive molecules containing an unpaired electron or an odd number of electrons.[1]. These reactive species are able to oxidize proteins, lipids or nucleic acids, and, thereby, have the potential to initiate oxidative stress and cause damage to cell structures, being, in turn, linked to chronic and degenerative diseases,[4] such
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