Synthesis, antimicrobial evaluation and QSAR studies of monochloroacetic acid derivatives

Abstract

In the present study, a series of monochloroacetic acid derivatives were synthesized and characterized by physicochemical and spectral means. Antimicrobial evaluation was performed against the Gram-positive bacteria: Staphylococcus aureus MTCC 2901, Bacillus subtilis MTCC 2063, Gram-negative bacterium: Escherichia coli MTCC 1652 and the fungal strains: Candida albicans MTCC 227 and Aspergillus niger MTCC 8189 using the tube dilution method. Results of antimicrobial screening indicated that compounds 10 and 17 were found to be most potent against C. albicans, having antifungal activity comparable to the standard drug fluconazole. mt-QSAR models indicated the importance of the steric parameter, molar refractivity (MR) in describing antibacterial and antimicrobial activities and the electronic parameter, total energy (Te) in describing antifungal activity of synthesized monochloroacetic acid derivatives.