Abstract
AbstractA series of novel 6‐substituted 2‐(benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acids were synthesized and characterized by 1H, 13C, 19F NMR, 1H‐1H‐COSY, 1H‐13C‐HSQC, NOESY, LC‐MS, IR, and elemental analysis. The mitotic toxicity of the synthesized compounds was determined according to the Allium test procedure. The 2‐(6‐(pentafluorophenyl)benzo[4,5]imidazo[1,2‐c]quinazolin‐5(6H)‐yl)acetic acid inhibited mitotic spindle formation, which resulted in significant cytotoxic effect for meristematic cells of Allium cepa l. roots. In a preliminary antimicrobial evaluation, only Streptococcus pyogenes and Candida albicans were slightly susceptible to some of the synthesized compounds.
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