Abstract
The diamino derivative is utilized to synthesize various substituted derivatives, which are characterized by IR and NMR. The antibacterial properties of synthesized compounds have been explored. Novel (E)-4,6-dibromo-N1- (4-substitutedbenzylidene)benzene-1,2-diamine derivatives ( 1-6 ) have been obtained in good yields from 2-amino-3,5-dibromobenzaldehyde and 4-substituted benzene-1,2 diamines in a single pot synthesis. The antimicrobial activity of the synthesized compounds have been screened against different strains such as Staphylococcus aureus , Bacillus subtilis , Streptococcus pyogenes , Klebsiella pneumoniae , Escherichia coli and compared with Ciprofloxacin as a standard and compound 6 shows significant activity against Staphylococcus aureus . The docking study results also support the antimicrobial activity data.
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