Abstract
A new series of 2-(3-chloroanilino)nicotinic acid hydrazides 12a–p were synthesized and evaluated for their anti-inflammatory and analgesic activities. Most of the compounds have shown anti-inflammatory activity with a moderate-to-excellent activity range. Among them, 3-chloro 12d and 4-methoxyphenyl derivatives 12i exhibited the most potent anti-inflammatory activity relative to niflumic acid as the reference drug (95, 87, and 81 % reductions in inflammation, respectively). The compounds with the highest anti-inflammatory activity were subjected to analgesic assay and showed moderate-to-excellent analgesic activities. The 2,4-dimethoxyphenyl derivative (12j) exhibited the highest analgesic activity relative to niflumic acid (99.6 and 68 % activity, respectively).
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