Abstract
The compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) was reacted with benzyl bromide to afford compound (1) which used as row material to prepare a series of compounds through condensation reaction, the starting compound were reacted with tosyl chloride to protect the OH group to afford compound 2, then reacted benzyl bromide to produce compound (2), then the compound (2) treated with three compounds ( 2-mercaptobenzthiazole, 2-mercaptobenimidazol and 2-chloromethyl benzimidazole) to form compounds 3a,b, 4a,b and 5a,b respectively. In the another step the click reaction of compound 2,2'-(((1H-benzo(d)imidazol-2-yl)methyl)azanediyl)bis(ethan-1-ol) with Propargyl bromide produce compound 6 which reacted with sodium azide or benzyl azide to afford the compounds 7 and 8. The synthesized compounds were characterized and measured the physical properties via the FT-IR, HNMR, besides to the CHN analysis. These newly compounds were screened their antibacterial and antifungal activity. Compounds 1, 2a and 8 showed significant antibacterial activity as well these compounds exhibited either low or moderated antifungal activity.
Highlights
The heterocyclic compounds are considering very important compound in many fields like the agriculture, industry and medicine application, the benzimidazole compounds are derivatives from the heterocyclic compounds Benzimidazole can be described as fused bicycle between benzene and imidazole
The most prominent benzimidazole compound in nature is N-ribosyldimethyl benzimidazole, which known as ligand for cobalt in vitamin B12 [13,14,15]
Due to the significant importance of benzimidazoles, a large numbers of methods have been reported for synthesizing benzimidazole derivatives and According to high biological activities of benzimidazole derivatives new benzimidazole containing some heterocyclic rings and test in vitro their preliminary antibacterial and antifungal activities
Summary
The heterocyclic compounds are considering very important compound in many fields like the agriculture, industry and medicine application, the benzimidazole compounds are derivatives from the heterocyclic compounds Benzimidazole can be described as fused bicycle between benzene and imidazole. The FTIR spectrum of this compound showed the broad band for OH at 3404 cm-1, while the NH of benzimidazole was disappeared from 3384 cm-1.
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