Abstract
Insufficient biological performances of titanium alloys have been the long‐standing problems for their clinical applications. Here, we report synthesis of novel hydroxyapatite/nanodiamond‐bone morphogenetic protein 2 (HA‐ND/BMP2) composite powder and their coatings deposited by vacuum cold spray operated at room temperature. The microstructure and chemistry of the HA‐ND/BMP2 powder and coatings are characterized by transmission electron microscopy, field‐emission scanning electron microscopy, thin‐film X‐ray diffraction, Raman spectrometry, and X‐ray photoelectron spectroscopy. In vitro growth assay of osteoblasts on the coatings showed that the biofunctionalized nanodiamonds promoted cell adhesion and proliferation. This study provides a promising technical route for constructing biofunctionalized nanocomposites coatings for potential biomedical applications.
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