Synthesis and Use of Tetrahydrofuran- and Tetrahydropyran-Amino Acids

Abstract

Progress in the synthesis and the use of amino acids containing a THF or THP ring is reported. Different synthetic routes from carbohydrates or α-amino acids as starting compounds are discussed. Examples for THF- and THP-amino acids as peptidomimetics or building blocks for foldamers and combinatorial libraries are given. The role of THF-amino acids in the synthesis of artificial ion channels, e.g. THF-gramicidin hybrids, is highlighted.