Abstract
A series of OEGylated poly(γ-benzyl-l-glutamate) with different oligo-ethylene-glycol side-chain length, molecular weight (MW = 8.4 × 103 to 13.5 × 104) and narrow molecular weight distribution (PDI = 1.12–1.19) can be readily prepared from triethylamine initiated ring-opening polymerization of OEGylated γ-benzyl-l-glutamic acid based N-carboxyanhydride. FTIR analysis revealed that the polymers adopted α-helical conformation in the solid-state. While they showed poor solubility in water, they exhibited a reversible upper critical solution temperature (UCST)-type phase behavior in various alcoholic organic solvents (i.e., methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, and isopropanol). Variable-temperature UV–vis analysis revealed that the UCST-type transition temperatures (Tpts) of the resulting polymers were highly dependent on the type of solvent, polymer concentration, side- and main-chain length. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015
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