Abstract
AbstractThe mutagens found in cooked meat, 2‐amino‐3‐methylimidazo[4,5‐f]‐quinoline (IQ) and 2‐amino‐3,4‐dimethylimidazo[4,5‐f]quinoline (Methyl ‐ IQ), have been synthesized by unambiguous methods that allow for the preparation of sufficient quantities of material for biological studies. These methods avoid difficult separations of regioisomeric mixtures of products and incorporate specific high level tritium, labeling, effected by hydrogenolysis of the appropriately substituted 5‐bromo precursors.
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