Abstract
Two oligonucleotides, partially modified with N,N-dimethylaminoethyl phosphoramidate groups, were obtained by an optimized solid-phase synthesis cycle based on H-phosphonate chemistry. Their use as third strands in parallel triple helices was shown to produce a decrease in stability with respect to all-phosphodiester oligonucleotide complexes, most probably due to unfavourable steric effects. Phosphoramidate-modified oligonucleotides were shown to be notably stable to exonucleases.
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