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Abstract
Pd(Eten)Cl2 complex, where Eten = N-ethylethylenediamine , was synthesized and characterized by elemental analysis and spectroscopic techniques. The stoichiometry and stability of the complexes formed between [Pd(Eten)(H2O)2]2+ and various biologically relevant ligands as adenine, adenosine, adenosine-5’-monophosphate and some selected peptides were investigated at 25ºC and 0.1 M ionic strength. The speciation diagrams of the complexes formed in solutions are evaluated. Thermodynamic parameters for Pd(Eten)-glycylglycine complexes were estimated.
Highlights
The use of platinum coordination compounds in cancer chemotherapy has been extensively investigated following the discovery of the therapeutic properties of cisplatin [cis-diamminedichloroplatinum(II)] by Rosenberg et al [1,2]
Despite the remarkable success of cisplatin, several problems have been found in clinical use
Cisplatin treatment is often accompanied by severe side effects, including cumulative toxicities of nephrotoxicity, neurotoxicity, and emetogenesis [5,6,9,10,11]
Summary
The use of platinum coordination compounds in cancer chemotherapy has been extensively investigated following the discovery of the therapeutic properties of cisplatin [cis-diamminedichloroplatinum(II)] by Rosenberg et al [1,2]. In the search for new platinum anticancer drugs, great efforts are devoted to the design of complexes more efficient and less toxic than the reference drugs already in clinical use. For this purpose, the rational design of complexes and the study of relevant structure–activity relationships have been extended to families of new compounds having high structural diversity. Pd(II) and Pt(II)-amine complexes have the same general structures and thermodynamic properties The former complexes are five orders of magnitude more reactive than their platinum counterparts. The ethyl group will create steric hindrance for the incoming ligand This will slow down the reactivity of the complexes to the same level as its platinum-amine analogues. The interaction of the Pd(II) complex with biorelevant ligands as peptides is studied
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