Synthesis and study the behavior of liquid crystalline phases of new heterocyclic compound from folic acid

Abstract

This work includes syntheses of new heterocyclic compounds of folic acid, The p-hydroxy benzaldehyde reaction with (pentanol, hexanol and heptanol) to produce (4-pentloxy, 4-hexaloxy and 4-hepteloxy) benzaldehyde, and compounds (p-hydroxy,p-chloro,p-nitro, 4-N,N-dimethyl) benzaldehyde and Vanillin reaction of folic acid with to produce Schiff bases. The Schiff base of benzaldehyde and Folic acid reaction with (4-pentloxy, 4- hexaloxy and4- hepteloxy) to produce Ester. The compounds have been identified using (FT-IR and 1H NMR). The misomorphic phases were identified by polarized light microscope (POM) and measured transition temperatures for compound by differrntion scanning calorimeter (DSC) then study of liquid crystal where it was found that compounds of (1-8) gave liquid crystalline properties, where the compounds (1,2,3,5,6,7and8) gave the nematic phase, but the compound (4) gave the smectic phase in addition to the nematic phase, while compounds (9,10and11) where oily compounds and showed not liquid crystalline properties.