Abstract
In this work, a novel family of salt-responsive polymeric hydrogel based on collagen was prepared via simultaneously graft copolymerization of acrylic monomers, acrylic acid (AA) and itaconic acid (IA) onto collagen backbones by a free radical polymerization technique using ammonium persulfate (APS) as initiator and methylene bisacrylamide (MBA) as a crosslinker. The effect of grafting variables, i.e. AA/IA weight ratio and concentration of MBA and APS, was systematically optimized to achieve a hydrogel with swelling capacity as high as possible. The water absorbency increased with increasing the AA/IA amount in the monomer feed due to formation of polyelectrolyte and then become constant. The swelling of the hydrogel samples in town water and saline solution (0.15 mol/L LiCl,NaCl,KCl, CaCl2 and AlCl3) was examined. Results indicated that the swelling capacity decreased with an increase charge of cation. This behavior can be attributed to charge screening effect for monovalent cations, as well as ionic crosslinking for multivalent cations.finally,a mechanism for hydrogel formation was proposed and the structure of the product was established using Fourier transform infrared (FTIR) and Scanning Electron Microscopy (SEM) spectroscopies. Also, thermogravimetric analysis showed the thermal stabilities of the hydrogels. Keywords: collagen, hydrogel, acrylic acid, itaconic acid, salt-responsive
Highlights
Swelling polymers, i.e. superabsorbent because of their non-toxicity, biocompatibility and hydrogels, are hydrophilic, three dimensional biodegradability
Acrylic acid (AA, such as polyacrylate, posses excellent water-absorbing Merck) was used after vacuum distillation. Their toxicity and non-biodegradability (IA, Merck) and ammonium persulfate (APS, Merck) was might pose long-time environmental problems and limit used without purification
A general reaction mechanism for collagen-based hydrogel formation is shown in Scheme 1
Summary
I.e. superabsorbent because of their non-toxicity, biocompatibility and hydrogels, are hydrophilic, three dimensional biodegradability. They are widely used in various applications such as hydrogels The hydrogels sharply and of natural-based superabsorbent hydrogels this work is reproducibly responding to the medium conditions are an attempt on the synthesis of a novel collagen - referred to as “responsive”,“smart” or “intelligent”. Acrylic acid (AA, such as polyacrylate, posses excellent water-absorbing Merck) was used after vacuum distillation Itaconic acid properties, their toxicity and non-biodegradability (IA, Merck) and ammonium persulfate (APS, Merck) was might pose long-time environmental problems and limit used without purification. The powdered superabsorbent was stored away from moisture, heat and light
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