Abstract
There were studied effects of analogs of conopressin S—a peptide of the vasopressin family with amino acid replacement at the 2nd and 4th positions (characteristic of invertebrate peptides)—on transport of water and ions in the rat kidney. Administration to female Wistar rats of 1-deamino-conopessin S produced a weak action on water transport and had no effect on K+ and Na+ excretion. Its analog, 1-deamino-Tyr2-conopressin S, caused antidiuretic and kaliuretic action without affecting Na+ excretion. Evaluation of significance of the variant of optic arginine isomer at the 4th and 8th position of the molecule for the antidiuretic and kaliuretic action of the peptide showed that 1-deamino-Tyr2,D-Arg4-conopressin S and 1-deamino-Tyr2,D-Arg4, 8-conopressin S did not affect the urinary K+ excretion and renal water reabsorption, whereas action of 1-deamino-Tyr2,D-Arg8-conopressin S did not differ from action of 1-deamino-Tyr2-conopressin S. Thus, it has been established that the selective kaliuretic action of conopressin S analogs on rat kidney depends on the presence of tyrosine at the 2nd and of L-arginine, but not of D-argynine, at the 4th position of the molecule.
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