Synthesis and Study of Antimicrobial Activity of 2-Dithiocarbamate-N-(9,10-Dioxo-9,10- Dihydroanthracenyl)Acetamides

Abstract

The global emergence and dissemination of multidrug-resistant fungal and bacterial pathogens is a serious public health threat. The development of novel highly active antimicrobial compounds simultaneously targeting several targets in bacterial or fungal pathogens could help to fight antimicrobial resistance. The four-component one-pot two-step facile synthesis of a new 2-dithiocarbamate-N-(9,10-dioxo-9,10-dihydroanthracenyl)acetamides 3a-n by the interaction of 2-chloro-N-(9,10-dioxo-9,10-dihydroanthracenyl)acetamide 1 or 2 with a series of in situ generated potassium salt of dithiocarbamic acids in DMF-H2O is presented. Evaluation of the antimicrobial activity of the synthesized compounds against bacteria strains Escherichia coli В-906, Staphylococcus aureus 209-Р, Mycobacterium luteumВ-917, and fungi Candida tenuis VKM Y-70, Aspergillus niger VKM F-1119 has been carried out by the diffusion in agar method and by the serial dilution technique. It has been established that synthesized compounds 3a, 3i, 3j have the good antibacterial activity against strain M. luteum at a concentration of 0.5% and the dithiocarbamates 3b, 3i, 3j, 3n demonstrate antifungal effect against C. tenuis at the same concentration. The results of the serial dilution technique showed that compound 3j has high antibacterial action at MIC 3.9 μg/ml.