Abstract
Several new Schiff’s base derivatives were prepared by condensing various substituted benzaldehyde with 1-(4-aminophenyl)-2-{4-[(S)-(4-chlorophenyl)(phenyl) methyl]-1-piperazinyl}ethanone in presence of acid catalyst under reflux condition. All the compounds were characterized by elemental analysis and spectral studies. The newly synthesized compounds were evaluated for their antibacterial and antifungal activity.
Highlights
Schiff’s base is a functional group or type of chemical compound containing a carbonnitrogen double bond with the nitrogen atom connected to an aryl group or an alkyl group but not hydrogen[1]
IR spectra showed absorption band at 1596 cm-1 indicated the stretching vibration of -CH=N (Schiff’s base) which confirming the condensation of reactants
The other peaks of IR spectra prove the structure of Schiff’s base derivatives. 1H NMR spectrum displayed signals for the presence of one imine proton (-CH=N) at 8.70 ppm (1H, s), one ketone group (-CO-CH2) at 3.39 ppm (2H, s), which confirms the condensation of reactants
Summary
Schiff’s base is a functional group or type of chemical compound containing a carbonnitrogen double bond with the nitrogen atom connected to an aryl group or an alkyl group but not hydrogen[1]. A mixture of 1-[(S)-(4-chlorophenyl)(phenyl)methyl]piperazine (35 g, 0.122 mol) [SOR:-20.18°] and N-[4-(2-bromoacetyl)phenyl]acetamide (32 g, 0.125 mol) was taken in methylene dichloride (140 mL).
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