Synthesis and studies of 6,6′-BINAP derivatives for the heterogeneous asymmetric hydrogenation of methyl acetoacetate

Abstract

New BINAP derivatives (polyamide, polyureas or ureas) were synthesized and employed in the ruthenium-catalyzed asymmetric heterogeneous hydrogenation of methyl acetoacetate. Enantiomeric excesses in the range 48–100% were observed. Furthermore, the most efficient have been recovered and the recycled catalysts were shown to maintain their efficiency in subsequent reactions.