Abstract
In this investigation, copper(II) complexes of 5-methoxy-salicylaldehyde-N1-substituted thiosemicarbazones {5-MeO-2-HOC6H4-C2(H)N3N2HC1(S)N1HR; R=Me, H2L-NMe; Et, H2L-NEt; Ph, H2L-NPh; H, H2L-NH2} with 2,9-dimethyl-1,10-phenanthroline (phen-2,9-Me2) and 3,4,7,8-tetramethyl-1,10-phenanthroline (phen-3,4,7,8-Me4) as co-ligands have been isolated. Complexes, namely, [Cu(κ3-O,N,S-L-NR)(κ2-N,N-L)] 1–8 (L=phen-2,9-Me2/phen-3,4,7,8-Me4) have been characterized by elemental analysis, infrared and electronic absorption spectroscopy, magnetic susceptibility measurements and single crystal X-ray crystallography. They have been studied for their fluorescence property, ESI mass study and antimicrobial activity against methicillin resistant Staphylococcus aureus (MRSA), Staphylococcus aureus (MTCC740), Klebsiella pneumoniae (MTCC109), Shigella flexneri (MTCC1457), Pseudomonas aeruginosa (MTCC741) and Candida albicans (MTCC227). Complexes, 1–8, have slightly distorted square pyramidal geometry and display intense fluorescence bands at λmax=403–426nm. ESI-mass spectral study has shown intense molecular ions [M+H]+. Copper(II) complexes have shown antimicrobial activity Complexes 5 and 6 with phenyl substitution at N1 nitrogen have shown enhanced antimicrobial activity with lowest minimum inhibitory concentration (MIC). The cellular toxicity against living cells was found to be high and thus these complexes are bactericidal/fungicidal.
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