Abstract
In this research, synthesis and characterization of a novel unsymmetric water-soluble porphyrin having three N-methylpyridinium and one lipoic acid-based meso-substituents were described. Effects of incorporation between a lipoic acid unit and a pyridinium-substituted porphyrin macrocycle, and the presence of Mn(II) as a metal center of the porphyrin ring on cytotoxicity of the compounds in Human keratinocyte (HaCaT) and Human dermal fibroblast, adult (HDFa) cells, and on mitochondria-targeting activity in the HaCaT cells were investigated. The biological studies revealed that the target lipoic acid-containing Mn(II)-porphyrin had low cytotoxicity with IC50 values bigger than 115 µM and of 87 µM in the HaCaT and HDFa cells, respectively. Moreover, this target compound also exhibited satisfactory mitochondria-targeting activity in the HaCaT cells.
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