Abstract
The reaction of 16,16-dimethyl-8-aza-D-1,3,5(10),13-tetraene-12,17a-dione (3,3-dimethyl-3,4,6,7,11b, 12-hexahydro-1H-[2.1-a]1,13(2H)-dione) with hydroxylamine and methoxyamine in ethanol gives the 12-methoxyamino and 12-methoxyamino derivatives. The 12-hydroxyamino derivative was also obtained by the reaction of this 12,17a-dione with hydroxylamine hydrochloride and subsequent cleavage of the hydrochloride salt of the 12-hydroxyamino derivative by the action of base. The 12-methoxyamino derivative was obtained by the methylation of the 12-hydroxyamino derivative using methyl iodide in the presence of sodium methylate. Further evidence for the structures of the derivatives obtained was obtained using COSY, NOESY, HMBC, and HMQC NMR spectroscopy.
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