Synthesis and Structure Elucidation for N-(2-pheny-4-thiazolidinone-3-yl)-2-(coumarin-4-yloxy)acetamide and Assessment Antibacterial Characteristics

Abstract

Coumarins are structurally motivating molecules for synthesizing pharmaceutical agents such as anticancer, anticoagulants, and antimicrobial. The structure of the synthesized coumarin derivative (N-(2-pheny-4-thiazolidinone-3-yl)-2-(coumarin-4-yloxy)acetamide) was elucidated by spectroscopically techniques. The bacterial inhibition efficiency of N-(2-pheny-4-thiazolidinone-3-yl)-2-(coumarin-4-yloxy)acetamide against selected types of bacteria, namely “Staphyloccocus aureus, as Gram-positive bacteria and Gram-negative bacteria Escherichia coli, Proteus vulgaris, Pseudomonas, and Klebsiella pneumoniae was determined utilizing a disc diffusion method. The scavenger effectiveness of the N-(2-pheny-4-thiazolidinone-3-yl)-2-(coumarin-4-yloxy)acetamide was also evaluated through the superoxide-radical method. The N-(2-pheny-4-thiazolidinone-3-yl)-2-(coumarin-4-yloxy)acetamide has significant inhibitive efficiency against all studied microorganism. The N-(2-pheny-4-thiazolidinone-3-yl)-2-(coumarin-4-yloxy)acetamide molecules have considerable activity as antioxidant compounds against vitamin C.