Synthesis and Structure Characterization of Thiazolyl-Pyrazoline Derivatives Bearing Quinoline Moiety

Abstract

A series of thiazolyl-pyrazoline derivatives containing the quinoline moiety were obtained by condensation of 2-bromo-1-phenyl-ethanone and 3-aryl-5-(2-substituted-quinolin-3-yl)-1-thiocarbamoyl-pyrazolines (4a-f). The structures of the newly synthesized compounds were characterized and their structures confirmed by IR, 1H NMR, mass spectrometry and elemental analysis. The solid-state structure of 3-(4-chlorophenyl)-5-(2-phenylthio-quinolin-3-yl)-1-(4-phenyl-2-thiazoyl)-pyrazoline (5n) was further studied by a single-crystal X-ray diffraction analysis. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: Figure S1 and Table S1.