Abstract
Isothiazole ( 8a,b), isoxazole ( 14) and thiophene ( 19a,b) analogues of the potent, M 1 selective muscarinic agonist, hexyloxy-TZTP, 1b, were synthesized and tested |in vitro for muscarinic receptor affinity and M 1 efficacy. All the analogues had lower affinity and efficacy at the M 1 muscarinic receptors than 1b.
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