Abstract
Malaria is a devastating world health problem. Using a compound library screening approach, we identified a novel series of disubstituted benzamide compounds with significant activity against malaria strains 3D7 and K1. These compounds represent a new antimalarial molecular scaffold exemplified by compound 1, which demonstrated EC50 values of 60 and 430nM against strains 3D7 and K1, respectively. Herein we report our findings on the efficient synthesis, structure–activity relationships, and biological activity of this new class of antimalarial agents.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have