Abstract
Curdlan, a natural linear (1→3)-β-D-glucan, was sulfated by piperidine-N-sulfonic acid in dimethyl sulfoxide to give curdlan sulfates with several molecular sizes and different sulfur contents. Curdlan sulfate with a sulfur content of 14.4% completely inhibited the infection of HIV in the drug concentration of as low as 3.3 μm/mL. This is one of the most potent anti-AIDS viral polysaccharides
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