Abstract
Synthesis of novel 225Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl2 with 0.2 mCi 225Ac furnished highly stable 225Ac tin colloid with 90% of radiochemical yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of radiochemical purity (RCP). Stability studies showed that colloidal structure also retained free daughter radionuclides formed by the 225Ac decay chain. 225Ac tin colloids could be ideal nanocarriers for localized cell killing due to high linear energy transfer and prevention of free radioisotope daughters.
Highlights
Radiosynovectomy (RSV) is a kind of local radiotherapy for joint synovitis and synovial processes [1] [2] [3]
Optimization of reaction medium and stability studies are of critical cases for exact synthesis of 225Ac tin colloid
Stability studies of 225Ac tin colloid have been well described for the first time
Summary
Radiosynovectomy (RSV) is a kind of local radiotherapy for joint synovitis and synovial processes [1] [2] [3]. Beta particle emitters such as 90Y [6], 188Re [7] and 169Er [8] have been frequently utilized for the treatment of different types of arthritis approved by European authorities [9]. The administration of those radiactive colloids depends on the size of the joints and amount of inflamation. 90Y colloid is mainly administered to larger size joint such as knee with approximately 5 - 6
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