Abstract
Seven new nitrophenol derivatives were synthesized; their 99mTc complexes (N2OS chelates), which are possible hypoxia tumor imaging agents, were prepared by the reaction with [99mTc]NaTcO4 in the presence of SnCl2 at pH 10. The in vitro biostabilty of the complexes was evaluated. The purity and stability (in human and rat serum) of the complexes were evaluated by chromatographic methods (TLC, HPLC). The most stable (for more than 6 h) is the complex of 99mTc with 3-[3′-N-(2″-hydroxy-5″-nitrobenzylamino)-2′-hydroxypropyl]-1-methylthiourea.
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