Abstract
A series of 2-amino-5-(substituted phenyl) 1,3,4- thiadiazol have been synthesized through the reaction of thiosemicarbazide with substituted benzoic acids in the presence of phosphoroxy chloride readily undergo nucleophilic addition – elimination reaction with chloroacetyl chloride in benzene as a solvent to afford 2-chloro acetamido compounds. The prepared compounds were subjected cyclization reaction and results in the formation of a series of 2- imino-3-(substituted phenyl) 1,3,4- thiadiazol-2yl-thiazolidinone -4 one . The IR ,1H and 13C- NMR spectra of the prepared compounds were confirmed to their proposed structures . Finally antimicrobial activity of the newly obtained compounds were tested against Klepsilla pneumonia (gram -ve ) and Staphylococcusaurous (gram + ve) and the results showed that most of the prepared compounds are sensitive against both types of test organisms in different activities .
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have